TARGETING EPIGENETICS IN CANCER

Por Bennett, Richard L., Licht, Jonathan D.
Publicado no Annu Rev Pharmacol Toxicol (2017)

c-Myc and Caspase-2 Are Involved in Activating Bax during Cytotoxic Drug-induced Apoptosis

Por Cao, Xuefang, Bennett, Richard L., May, W. Stratford
Publicado em 2008

Progressive Genomic Instability in the Nup98-HoxD13 Model of MDS Correlates with Loss of the PIG-A Gene Product()()

Por Byrne, Michael, Bennett, Richard L., Cheng, Xiaodong, Stratford May, W.
Publicado no Neoplasia (2014)

The Role of Nuclear Receptor–Binding SET Domain Family Histone Lysine Methyltransferases in Cancer

Por Bennett, Richard L., Swaroop, Alok, Troche, Catalina, Licht, Jonathan D.
Publicado no Cold Spring Harb Perspect Med (2017)

The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest

Por Bennett, Richard L, Pan, Yu, Christian, Jamie, Hui, Teng, May, W Stratford
Publicado em 2012

PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells

Por Liu, Xiangfei, Bennett, Richard L., Cheng, Xiaodong, Byrne, Michael, Reinhard, Mary K., May, W. Stratford
Publicado em 2013

Increased Expression of the dsRNA-Activated Protein Kinase PKR in Breast Cancer Promotes Sensitivity to Doxorubicin

Por Bennett, Richard L., Carruthers, Aubrey L., Hui, Teng, Kerney, Krystal R., Liu, Xiangfei, May, W. Stratford
Publicado em 2012

RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection

Por Bennett, Richard L., Blalock, William L., Abtahi, Dean M., Pan, Yu, Moyer, Sue A., May, W. Stratford
Publicado em 2006

PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice

Por Cheng, Xiaodong, Byrne, Michael, Brown, Kevin D., Konopleva, Marina Y., Kornblau, Steven M., Bennett, Richard L., May, W. Stratford
Publicado no Blood (2015)

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

Por Huang, Xiaoxiao, LeDuc, Richard D., Fornelli, Luca, Schunter, Alissa J., Bennett, Richard L., Kelleher, Neil L., Licht, Jonathan D.
Publicado no J Biol Chem (2019)

RAX is required for fly neuronal development and mouse embryogenesis

Por Bennett, Richard L., Blalock, William L., Choi, Eun-Jung, Lee, Young J., Zhang, Yanping, Zhou, Lei, Oh, S. Paul, May, W. Stratford
Publicado em 2008

Sabotaging of the oxidative stress response by an oncogenic noncoding RNA

Por Mahajan, Nitin, Wu, Hua-Jun, Bennett, Richard L., Troche, Catalina, Licht, Jonathan D., Weber, Jason D., Maggi, Leonard B., Tomasson, Michael H.
Publicado no FASEB J (2017)

An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia

Por Swaroop, Alok, Oyer, Jon A., Will, Christine M., Huang, Xiaoxiao, Yu, Wenbo, Troche, Catalina, Bulic, Marinka, Durham, Benjamin H., Wen, Qiang Jeremy, Crispino, John D., MacKerell, Alexander D., Bennett, Richard L., Kelleher, Neil L., Licht, Jonathan D.
Publicado no Oncogene (2018)

A Mutation in Histone H2B Represents A New Class Of Oncogenic Driver

Por Bennett, Richard L., Bele, Aditya, Small, Eliza C., Will, Christine M., Nabet, Behnam, Oyer, Jon A., Huang, Xiaoxiao, Ghosh, Rajarshi P., Grzybowski, Adrian T., Yu, Tao, Zhang, Qiao, Riva, Alberto, Lele, Tanmay P., Schatz, George C., Kelleher, Neil L., Ruthenburg, Alexander J., Liphardt, Jan, Licht, Jonathan D.
Publicado no Cancer Discov (2019)