Progress in Top-Down Proteomics and the Analysis of Proteoforms

Por Toby, Timothy K., Fornelli, Luca, Kelleher, Neil L.
Publicado no Annu Rev Anal Chem (Palo Alto Calif) (2016)

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

Por Doubleday, Peter F., Fornelli, Luca, Kelleher, Neil L.
Publicado no J Proteome Res (2020)

Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry

Por Compton, Philip D., Fornelli, Luca, Kelleher, Neil L., Skinner, Owen S.
Publicado no Int J Mass Spectrom (2015)

The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics

Por Lyon, Yana A., Riggs, Dylan, Fornelli, Luca, Compton, Philip D., Julian, Ryan R.
Publicado no J Am Soc Mass Spectrom (2017)

Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite

Por DeHart, Caroline J., Fellers, Ryan T., Fornelli, Luca, Kelleher, Neil L., Thomas, Paul M.
Publicado no Methods Mol Biol (2017)

Chromatographic Efficiency and Selectivity in Top-down Proteomics of Histones

Por Zhou, Yiyang, Zhang, Ximo, Fornelli, Luca, Compton, Philip D., Kelleher, Neil, Wirth, Mary J.
Publicado no J Chromatogr B Analyt Technol Biomed Life Sci (2016)

Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa

Por Durbin, Kenneth R., Fornelli, Luca, Fellers, Ryan T., Doubleday, Peter F., Narita, Masashi, Kelleher, Neil L.
Publicado no J Proteome Res (2016)

Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics

Por Melani, Rafael D., Skinner, Owen S., Fornelli, Luca, Domont, Gilberto B., Compton, Philip D., Kelleher, Neil L.
Publicado no Mol Cell Proteomics (2016)

A comprehensive pipeline for translational top-down proteomics from a single blood draw

Por Toby, Timothy K., Fornelli, Luca, Srzentić, Kristina, DeHart, Caroline J., Levitsky, Josh, Friedewald, John, Kelleher, Neil L.
Publicado no Nat Protoc (2019)

Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS

Por Fornelli, Luca, Damoc, Eugen, Thomas, Paul M., Kelleher, Neil L., Aizikov, Konstantin, Denisov, Eduard, Makarov, Alexander, Tsybin, Yury O.
Publicado em 2012

Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry

Por Melani, Rafael D., Srzentić, Kristina, Gerbasi, Vincent R., McGee, John P., Huguet, Romain, Fornelli, Luca, Kelleher, Neil L.
Publicado no MAbs (2019)

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry

Por Savaryn, John Paul, Skinner, Owen S., Fornelli, Luca, Fellers, Ryan T., Compton, Philip D., Terhune, Scott S., Abecassis, Mike M., Kelleher, Neil L.
Publicado no J Proteomics (2015)

Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer

Por Fornelli, Luca, Ayoub, Daniel, Aizikov, Konstantin, Liu, Xiaowen, Damoc, Eugen, Pevzner, Pavel A., Makarov, Alexander, Beck, Alain, Tsybin, Yury O.
Publicado no J Proteomics (2017)

Top-down proteomics: where we are, where we are going?

Por Fornelli, Luca, Toby, Timothy K., Schachner, Luis F., Doubleday, Peter F., Srzentić, Kristina, DeHart, Caroline J., Kelleher, Neil L.
Publicado no J Proteomics (2017)

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

Por Huang, Xiaoxiao, LeDuc, Richard D., Fornelli, Luca, Schunter, Alissa J., Bennett, Richard L., Kelleher, Neil L., Licht, Jonathan D.
Publicado no J Biol Chem (2019)

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms

Por Huguet, Romain, Mullen, Christopher, Srzentić, Kristina, Greer, Joseph B., Fellers, Ryan T., Zabrouskov, Vlad, Syka, John E. P., Kelleher, Neil L., Fornelli, Luca
Publicado no Anal Chem (2019)

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer

Por Fornelli, Luca, Durbin, Kenneth R., Fellers, Ryan T., Early, Bryan P., Greer, Joseph B., LeDuc, Richard D., Compton, Philip D., Kelleher, Neil L.
Publicado no J Proteome Res (2016)

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

Por Fornelli, Luca, Srzentić, Kristina, Huguet, Romain, Mullen, Christopher, Sharma, Seema, Zabrouskov, Vlad, Fellers, Ryan T., Durbin, Kenneth R., Compton, Philip D., Kelleher, Neil L.
Publicado no Anal Chem (2018)

Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry

Por van der Burgt, Yuri E.M., Kilgour, David P. A., Tsybin, Yury O., Srzentić, Kristina, Fornelli, Luca, Beck, Alain, Wuhrer, Manfred, Nicolardi, Simone
Publicado no Anal Chem (2018)

Defining gas-phase fragmentation propensities of intact proteins during native top-down mass spectrometry

Por Haverland, Nicole A., Skinner, Owen S., Fellers, Ryan T., Tariq, Areeba A., Early, Bryan P., LeDuc, Richard D., Fornelli, Luca, Compton, Philip D., Kelleher, Neil L.
Publicado no J Am Soc Mass Spectrom (2017)