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Progress in Top-Down Proteomics and the Analysis of Proteoforms

From a molecular perspective, enactors of function in biology are intact proteins that can be variably modified at the genetic, transcriptional, or post-translational level. Over the past 30 years, mass spectrometry (MS) has become a powerful method for the analysis of proteomes. Prevailing bottom-u...

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Détails bibliographiques
Publié dans:Annu Rev Anal Chem (Palo Alto Calif)
Auteurs principaux: Toby, Timothy K., Fornelli, Luca, Kelleher, Neil L.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373801/
https://ncbi.nlm.nih.gov/pubmed/27306313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-anchem-071015-041550
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