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A comprehensive pipeline for translational top-down proteomics from a single blood draw

Top-down proteomics (TDP) by mass spectrometry (MS) is a technique by which intact proteins are analyzed. It has become increasingly popular in translational research because of the value of characterizing distinct proteoforms of intact proteins. Compared to bottom-up proteomics (BUP) strategies, wh...

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Detalhes bibliográficos
Publicado no:Nat Protoc
Main Authors: Toby, Timothy K., Fornelli, Luca, Srzentić, Kristina, DeHart, Caroline J., Levitsky, Josh, Friedewald, John, Kelleher, Neil L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439476/
https://ncbi.nlm.nih.gov/pubmed/30518910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-018-0085-7
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