Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

Targeted top-down (TD) and middle-down (MD) mass spectrometry (MS) offer reduced sample manipulation during protein analysis, limiting the risk of introducing artifactual modifications to better capture sequence information on the proteoforms present. This provides some advantages when characterizin...

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Udgivet i:Anal Chem
Main Authors: Fornelli, Luca, Srzentić, Kristina, Huguet, Romain, Mullen, Christopher, Sharma, Seema, Zabrouskov, Vlad, Fellers, Ryan T., Durbin, Kenneth R., Compton, Philip D., Kelleher, Neil L.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071867/
https://ncbi.nlm.nih.gov/pubmed/29894161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b00984
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