Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression

Histones, and their modifications, are critical components of cellular programming and epigenetic inheritance. Recently, cancer genome sequencing has uncovered driver mutations in chromatin modifying enzymes spurring high interest how such mutations change histone modification patterns. Here, we app...

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Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Zheng, Yupeng, Fornelli, Luca, Compton, Philip D., Sharma, Seema, Canterbury, Jesse, Mullen, Christopher, Zabrouskov, Vlad, Fellers, Ryan T., Thomas, Paul M., Licht, Jonathan D., Senko, Michael W., Kelleher, Neil L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Special Issue: Chromatin Biology and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813700/
https://ncbi.nlm.nih.gov/pubmed/26272979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.053819
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