Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression

Histones, and their modifications, are critical components of cellular programming and epigenetic inheritance. Recently, cancer genome sequencing has uncovered driver mutations in chromatin modifying enzymes spurring high interest how such mutations change histone modification patterns. Here, we app...

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Foilsithe in:Mol Cell Proteomics
Main Authors: Zheng, Yupeng, Fornelli, Luca, Compton, Philip D., Sharma, Seema, Canterbury, Jesse, Mullen, Christopher, Zabrouskov, Vlad, Fellers, Ryan T., Thomas, Paul M., Licht, Jonathan D., Senko, Michael W., Kelleher, Neil L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Special Issue: Chromatin Biology and Epigenetics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813700/
https://ncbi.nlm.nih.gov/pubmed/26272979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.053819
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