Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

NSD2 is a histone methyltransferase that specifically dimethylates histone H3 lysine 36 (H3K36me2), a modification associated with gene activation. Dramatic overexpression of NSD2 in t(4;14) multiple myeloma (MM) and an activating mutation of NSD2 discovered in acute lymphoblastic leukemia are signi...

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Vydáno v:J Biol Chem
Hlavní autoři: Huang, Xiaoxiao, LeDuc, Richard D., Fornelli, Luca, Schunter, Alissa J., Bennett, Richard L., Kelleher, Neil L., Licht, Jonathan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Genomics and Proteomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699848/
https://ncbi.nlm.nih.gov/pubmed/31248990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006159
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