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PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation

Poly (ADP-ribose) polymerase (PARP) 1 is an essential molecule in DNA damage response by sensing DNA damage and docking DNA repair proteins on the damaged DNA site through a type of posttranslational modification, poly (ADP-Ribosyl)ation (PARylation). PARP inhibitors, which inhibit PARylation throug...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Min, Ahrum, Im, Seock-Ah
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072193/
https://ncbi.nlm.nih.gov/pubmed/32046300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020394
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