A carregar...
Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies
While poly(ADP-ribosyl)ation (PARylation) plays an important role in DNA repair, the role of dePARylation in DNA repair remains elusive. Here, we report that a novel small molecule identified from the NCI database, COH34, specifically inhibits poly(ADP-ribose) glycohydrolase (PARG), the major dePARy...
Na minha lista:
| Publicado no: | Sci Adv |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2019
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6457938/ https://ncbi.nlm.nih.gov/pubmed/30989114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav4340 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|