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Targeting dePARylation for cancer therapy
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects. Thus, PARP inhibitors have been approved by the...
Gorde:
| Argitaratua izan da: | Cell Biosci |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
BioMed Central
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6988220/ https://ncbi.nlm.nih.gov/pubmed/32010441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-0375-y |
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