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Targeting dePARylation for cancer therapy
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects. Thus, PARP inhibitors have been approved by the...
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| 出版年: | Cell Biosci |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6988220/ https://ncbi.nlm.nih.gov/pubmed/32010441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-0375-y |
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