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Targeting dePARylation for cancer therapy
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects. Thus, PARP inhibitors have been approved by the...
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| Publicat a: | Cell Biosci |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6988220/ https://ncbi.nlm.nih.gov/pubmed/32010441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-0375-y |
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