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Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets
Poly (ADP-ribose)ylation is a dynamic protein modification that regulates multiple cellular processes. Here, we describe a system for identifying and characterizing PARylation events that exploits the ability of a PBZ (PAR-binding zinc finger) protein domain to bind PAR with high-affinity. By linkin...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5964205/ https://ncbi.nlm.nih.gov/pubmed/29789535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04466-4 |
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