Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets

Poly (ADP-ribose)ylation is a dynamic protein modification that regulates multiple cellular processes. Here, we describe a system for identifying and characterizing PARylation events that exploits the ability of a PBZ (PAR-binding zinc finger) protein domain to bind PAR with high-affinity. By linkin...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Krastev, Dragomir B., Pettitt, Stephen J., Campbell, James, Song, Feifei, Tanos, Barbara E., Stoynov, Stoyno S., Ashworth, Alan, Lord, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964205/
https://ncbi.nlm.nih.gov/pubmed/29789535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04466-4
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky