An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence

BACKGROUND: Cellular senescence is an irreversible cell cycle arrest that normal cells undergo in response to progressive shortening of telomeres, changes in telomeric structure, oncogene activation or oxidative stress and acts as an important tumour suppressor mechanism. RESULTS: To identify the do...

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Hlavní autoři: Rovillain, Emilie, Mansfield, Louise, Lord, Christopher J, Ashworth, Alan, Jat, Parmjit S
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161017/
https://ncbi.nlm.nih.gov/pubmed/21740549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-355
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