pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location

pRb is frequently inactivated in tumours by mutations or phosphorylation. Here, we investigated whether pRb plays a role in obesity. The Arcuate nucleus (ARC) in hypothalamus contains antagonizing POMC and AGRP/NPY neurons for negative and positive energy balance, respectively. Various aspects of AR...

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Detalhes bibliográficos
Main Authors: Lu, Zhonglei, Marcelin, Genevieve, Bauzon, Frederick, Wang, Hongbo, Fu, Hao, Dun, Siok Le, Zhao, Hongling, Li, Xiaosong, Jo, Young-Hwan, Wardlaw, Sharon, Dun, Nae, Chua, Streamson, Zhu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604720/
https://ncbi.nlm.nih.gov/pubmed/23403926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.25
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