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Antitumor mechanisms when pRb and p53 are genetically inactivated

pRb and p53 are the two major tumor suppressors. Their inactivation is frequent when cancers develop and their reactivation is rationale of most cancer therapeutics. When pRb and p53 are genetically inactivated, cells irreparably lose the antitumor mechanisms afforded by them. Cancer genome studies...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Zhu, Liang, Lu, Zhonglei, Zhao, Hongling
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459916/
https://ncbi.nlm.nih.gov/pubmed/25486431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.399
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