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Antitumor mechanisms when pRb and p53 are genetically inactivated
pRb and p53 are the two major tumor suppressors. Their inactivation is frequent when cancers develop and their reactivation is rationale of most cancer therapeutics. When pRb and p53 are genetically inactivated, cells irreparably lose the antitumor mechanisms afforded by them. Cancer genome studies...
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| Опубликовано в: : | Oncogene |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4459916/ https://ncbi.nlm.nih.gov/pubmed/25486431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.399 |
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