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Antitumor mechanisms when pRb and p53 are genetically inactivated

pRb and p53 are the two major tumor suppressors. Their inactivation is frequent when cancers develop and their reactivation is rationale of most cancer therapeutics. When pRb and p53 are genetically inactivated, cells irreparably lose the antitumor mechanisms afforded by them. Cancer genome studies...

詳細記述

保存先:
書誌詳細
出版年:Oncogene
主要な著者: Zhu, Liang, Lu, Zhonglei, Zhao, Hongling
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459916/
https://ncbi.nlm.nih.gov/pubmed/25486431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.399
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