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Antitumor mechanisms when pRb and p53 are genetically inactivated
pRb and p53 are the two major tumor suppressors. Their inactivation is frequent when cancers develop and their reactivation is rationale of most cancer therapeutics. When pRb and p53 are genetically inactivated, cells irreparably lose the antitumor mechanisms afforded by them. Cancer genome studies...
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| 出版年: | Oncogene |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4459916/ https://ncbi.nlm.nih.gov/pubmed/25486431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.399 |
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