Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors

pRb and p53 are two major tumor suppressors. Here, we found that p53 activates expression of Pirh2 and KPC1, two of the three ubiquitin ligases for p27. Loss of p53 in the absence of Skp2, the third ubiquitin ligase for p27, shrinks the cellular pool of p27 ubiquitin ligases to accumulate p27 protei...

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Main Authors: Zhao, Hongling, Bauzon, Frederick, Fu, Hao, Lu, Zhonglei, Cui, Jinhua, Nakayama, Keiko, Nakayama, Keiich I., Locker, Joseph, Zhu, Liang
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880806/
https://ncbi.nlm.nih.gov/pubmed/24229711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.09.021
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