Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1(+/-) mice

Heterozygosity of the retinoblastoma gene Rb1 elicits tumorigenesis in susceptible tissues following spontaneous loss of the remaining functional allele. Inactivation of previously studied pRb targets partially inhibited tumorigenesis in Rb1(+/-) mice 1,2,3,4,5,6. Here, we report that inactivation o...

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Main Authors: Wang, Hongbo, Bauzon, Frederick, Ji, Peng, Xu, Xiaoliang, Sun, Daqian, Locker, Joseph, Sellers, Rani S., Nakayama, Keiko, Nakayama, Keiich I., Cobrinik, David, Zhu, Liang
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990528/
https://ncbi.nlm.nih.gov/pubmed/19966802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.498
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