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Skp2 suppresses apoptosis in Rb1 deficient tumors by limiting E2F1 activity

One mechanism of tumor suppression by pRb is repressing E2F1. Hence, E2f1 deletion diminishes tumorigenesis following Rb1 loss. However, E2F1 promotes both proliferation and apoptosis. It therefore remains unclear how de-repressed E2F1 promotes tumorigenesis. Another mechanism of pRb function is rep...

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Detalhes bibliográficos
Main Authors: Lu, Zhonglei, Bauzon, Frederick, Fu, Hao, Cui, Jinhua, Zhao, Hongling, Nakayama, Keiko, Nakayama, Keiich I., Zhu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982150/
https://ncbi.nlm.nih.gov/pubmed/24632684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4463
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