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Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis
Tumor suppressor pRb represses Skp2, a substrate-recruiting subunit of the SCF(Skp2) ubiquitin ligase. Rb1(+/−) mice incur “two-hit” pituitary tumorigenesis; Skp2(−/−);Rb1(+/−) mice do not. Rb1(−/−) embryos die on embryonic day (E) 14.5–15.5. Here, we report that Skp2(−/−);Rb1(−/−) embryos died on E...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4858970/ https://ncbi.nlm.nih.gov/pubmed/26966181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718049 |
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