Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis

Tumor suppressor pRb represses Skp2, a substrate-recruiting subunit of the SCF(Skp2) ubiquitin ligase. Rb1(+/−) mice incur “two-hit” pituitary tumorigenesis; Skp2(−/−);Rb1(+/−) mice do not. Rb1(−/−) embryos die on embryonic day (E) 14.5–15.5. Here, we report that Skp2(−/−);Rb1(−/−) embryos died on E...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Zhao, Hongling, Wang, Hongbo, Bauzon, Frederick, Lu, Zhonglei, Fu, Hao, Cui, Jinhua, Zhu, Liang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858970/
https://ncbi.nlm.nih.gov/pubmed/26966181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718049
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