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Skp2 suppresses apoptosis in Rb1 deficient tumors by limiting E2F1 activity
One mechanism of tumor suppression by pRb is repressing E2F1. Hence, E2f1 deletion diminishes tumorigenesis following Rb1 loss. However, E2F1 promotes both proliferation and apoptosis. It therefore remains unclear how de-repressed E2F1 promotes tumorigenesis. Another mechanism of pRb function is rep...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3982150/ https://ncbi.nlm.nih.gov/pubmed/24632684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4463 |
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