Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1(+/-) mice

Heterozygosity of the retinoblastoma gene Rb1 elicits tumorigenesis in susceptible tissues following spontaneous loss of the remaining functional allele. Inactivation of previously studied pRb targets partially inhibited tumorigenesis in Rb1(+/-) mice 1,2,3,4,5,6. Here, we report that inactivation o...

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Библиографические подробности
Главные авторы: Wang, Hongbo, Bauzon, Frederick, Ji, Peng, Xu, Xiaoliang, Sun, Daqian, Locker, Joseph, Sellers, Rani S., Nakayama, Keiko, Nakayama, Keiich I., Cobrinik, David, Zhu, Liang
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990528/
https://ncbi.nlm.nih.gov/pubmed/19966802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.498
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