SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells

Germline RB1 mutations strongly predispose humans to cone-precursor-derived retinoblastomas and strongly predispose mice to pituitary tumors, yet shared cell type-specific circuitry that sensitizes these different cell types to the loss of RB1 has not been defined. Here we show that the cell type-re...

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Publicado en:Cancer Res
Main Authors: Xu, Xiaoliang L., Li, Zhengke, Liu, Aihong, Fan, Xianqun, Hu, Dan-ning, Qi, Dong-Lai, Chitty, David W., Jia, Renbing, Qui, Jianping, Wang, Justin Q., Sharaf, Jake, Zou, Jun, Weiss, Rebecca, Huang, Hongyan, Joseph, Walter J., Ng, Lily, Rosen, Richard, Shen, Binghui, Reid, Mark W., Forrest, Douglas, Abramson, David H., Singer, Samuel, Cobrinik, David, Jhanwar, Suresh C.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732859/
https://ncbi.nlm.nih.gov/pubmed/28972075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3299
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