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Phosphorylation puts the pRb tumor suppressor into shape
In this issue of Genes & Development, Burke and colleagues (pp. 1156–1166) describe how the structure of retinoblastoma protein (pRb) is altered by phosphorylation at T373 or S608. These modifications cause specific conformational changes and alter pRb's interaction with E2F via two distinc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371403/ https://ncbi.nlm.nih.gov/pubmed/22661226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.195552.112 |
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