טוען...
Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies
While poly(ADP-ribosyl)ation (PARylation) plays an important role in DNA repair, the role of dePARylation in DNA repair remains elusive. Here, we report that a novel small molecule identified from the NCI database, COH34, specifically inhibits poly(ADP-ribose) glycohydrolase (PARG), the major dePARy...
שמור ב:
| הוצא לאור ב: | Sci Adv |
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| Main Authors: | , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Association for the Advancement of Science
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6457938/ https://ncbi.nlm.nih.gov/pubmed/30989114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav4340 |
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