An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia

NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL), and cells harboring this mutation can become the predominant clone in relapsing disease. We s...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Swaroop, Alok, Oyer, Jon A., Will, Christine M., Huang, Xiaoxiao, Yu, Wenbo, Troche, Catalina, Bulic, Marinka, Durham, Benjamin H., Wen, Qiang Jeremy, Crispino, John D., MacKerell, Alexander D., Bennett, Richard L., Kelleher, Neil L., Licht, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358490/
https://ncbi.nlm.nih.gov/pubmed/30171259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0474-y
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