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The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest
Cellular stresses, including growth factor deprivation, inflammatory cytokines or viral infection promote RAX/PACT-dependent activation of the double-stranded RNA-dependent protein kinase, PKR, to phosphorylate eIF2α, resulting in translation inhibition and apoptosis. In addition, PKR has been repor...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293386/ https://ncbi.nlm.nih.gov/pubmed/22214662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.2.18999 |
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