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BIOCHEMICAL ANALYSIS OF PKR ACTIVATION BY PACT

Many extracellular stresses cause inhibition of translation initiation by triggering phosphorylation of the initiation factor, eIF-2α. A major protein kinase responsible for this phosphorylation is PKR, a latent kinase which itself needs activation by autophosphorylation. In stressed cells, this act...

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Détails bibliographiques
Auteurs principaux: Peters, Gregory A., Dickerman, Benjamin, Sen, Ganes C.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766932/
https://ncbi.nlm.nih.gov/pubmed/19580324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900433y
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