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Modular Structure of PACT: Distinct Domains for Binding and Activating PKR
PACT is a 35-kDa human protein that can directly bind and activate the latent protein kinase, PKR. Here we report that PKR activation by PACT causes cellular apoptosis in addition to PKR autophosphorylation and translation inhibition. We analyzed the structure-function relationship of PACT by measur...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC86773/ https://ncbi.nlm.nih.gov/pubmed/11238927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.6.1908-1920.2001 |
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