Modular Structure of PACT: Distinct Domains for Binding and Activating PKR

PACT is a 35-kDa human protein that can directly bind and activate the latent protein kinase, PKR. Here we report that PKR activation by PACT causes cellular apoptosis in addition to PKR autophosphorylation and translation inhibition. We analyzed the structure-function relationship of PACT by measur...

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Bibliografiske detaljer
Main Authors: Peters, Gregory A., Hartmann, Rune, Qin, Jun, Sen, Ganes C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86773/
https://ncbi.nlm.nih.gov/pubmed/11238927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.6.1908-1920.2001
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