PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice

Increased expression of the interferon-inducible double-stranded RNA-activated protein kinase (PKR) has been reported in acute leukemia and solid tumors, but the role of PKR has been unclear. Now, our results indicate that high PKR expression in CD34(+) cells of acute myeloid leukemia (AML) patients...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Cheng, Xiaodong, Byrne, Michael, Brown, Kevin D., Konopleva, Marina Y., Kornblau, Steven M., Bennett, Richard L., May, W. Stratford
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2015
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582335/
https://ncbi.nlm.nih.gov/pubmed/26202421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-635227
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