PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice

Increased expression of the interferon-inducible double-stranded RNA-activated protein kinase (PKR) has been reported in acute leukemia and solid tumors, but the role of PKR has been unclear. Now, our results indicate that high PKR expression in CD34(+) cells of acute myeloid leukemia (AML) patients...

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Publicado en:Blood
Main Authors: Cheng, Xiaodong, Byrne, Michael, Brown, Kevin D., Konopleva, Marina Y., Kornblau, Steven M., Bennett, Richard L., May, W. Stratford
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2015
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582335/
https://ncbi.nlm.nih.gov/pubmed/26202421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-635227
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