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Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors

Janus kinases (JAK) are the mediators of a variety of cytokine signals via their cognate receptors that result in activation of intracellular signaling pathways. Alterations in JAK1, JAK2, JAK3 and TYK2 signaling contribute to different disease states, and dysregulated JAK-STAT signaling is associat...

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Detalhes bibliográficos
Main Authors: Meyer, Sara C., Levine, Ross L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990645/
https://ncbi.nlm.nih.gov/pubmed/24583800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0279
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