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Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
Janus kinase-2 (JAK2) mediates signaling by various cytokines, including erythropoietin and growth hormone. JAK2 possesses tandem pseudokinase and tyrosine kinase domains. Mutations in the pseudokinase domain are causally linked to myeloproliferative neoplasms (MPNs) in humans. The structure of the...
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| Yayımlandı: | Nat Struct Mol Biol |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4508010/ https://ncbi.nlm.nih.gov/pubmed/24918548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2849 |
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