ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

Pseudokinases lack conserved motifs typically required for kinase activity. Nearly half of pseudokinases bind ATP, but only few retain phosphotransfer activity, leaving the functional role of nucleotide binding in most cases unknown. Janus kinases (JAKs) are nonreceptor tyrosine kinases with a tande...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Hammarén, Henrik M., Ungureanu, Daniela, Grisouard, Jean, Skoda, Radek C., Hubbard, Stevan R., Silvennoinen, Olli
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403165/
https://ncbi.nlm.nih.gov/pubmed/25825724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423201112
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