Yüklüyor......
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
Pseudokinases lack conserved motifs typically required for kinase activity. Nearly half of pseudokinases bind ATP, but only few retain phosphotransfer activity, leaving the functional role of nucleotide binding in most cases unknown. Janus kinases (JAKs) are nonreceptor tyrosine kinases with a tande...
Kaydedildi:
| Yayımlandı: | Proc Natl Acad Sci U S A |
|---|---|
| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2015
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4403165/ https://ncbi.nlm.nih.gov/pubmed/25825724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423201112 |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|