Hyperactivation of Oncogenic JAK3 Mutants Depend on ATP Binding to the Pseudokinase Domain

Janus kinase 3 (JAK3) tyrosine kinase has a central role in the control of lymphopoiesis, and mutations in JAK3 can lead to either severe combined immunodeficiency or leukemia and lymphomas. JAK3 associates with the common gamma chain (γc) receptor and functions in a heteromeric signaling pair with...

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Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Raivola, Juuli, Hammarén, Henrik M., Virtanen, Anniina T., Bulleeraz, Vilasha, Ward, Alister C., Silvennoinen, Olli
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287396/
https://ncbi.nlm.nih.gov/pubmed/30560087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00560
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