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Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders
[Image: see text] Janus kinases (JAKs) regulate hematopoiesis via the cytokine-mediated JAK-STAT signaling pathway. JAKs contain tandem C-terminal pseudokinase (JH2) and tyrosine kinase (JH1) domains. The JAK2 pseudokinase domain adopts a protein kinase fold and, despite its pseudokinase designation...
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| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2017
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467198/ https://ncbi.nlm.nih.gov/pubmed/28626521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00153 |
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