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Crystal structures of the Jak2 pseudokinase domain and the pathogenic mutant V617F

The protein tyrosine kinase Jak2 mediates signaling through numerous cytokine receptors. Jak2 possesses a pseudokinase domain (JH2) and a tyrosine kinase domain (JH1). Through unknown mechanisms, JH2 regulates the catalytic activity of JH1, and hyperactivating mutations in the JH2 region of human Ja...

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Autori principali: Bandaranayake, Rajintha M., Ungureanu, Daniela, Shan, Yibing, Shaw, David E., Silvennoinen, Olli, Hubbard, Stevan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414675/
https://ncbi.nlm.nih.gov/pubmed/22820988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2348
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