ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

Pseudokinases lack conserved motifs typically required for kinase activity. Nearly half of pseudokinases bind ATP, but only few retain phosphotransfer activity, leaving the functional role of nucleotide binding in most cases unknown. Janus kinases (JAKs) are nonreceptor tyrosine kinases with a tande...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hammarén, Henrik M., Ungureanu, Daniela, Grisouard, Jean, Skoda, Radek C., Hubbard, Stevan R., Silvennoinen, Olli
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403165/
https://ncbi.nlm.nih.gov/pubmed/25825724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423201112
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker