Autoinhibition of Jak2 Tyrosine Kinase Is Dependent on Specific Regions in Its Pseudokinase Domain
Jak tyrosine kinases have a unique domain structure containing a kinase domain (JH1) adjacent to a catalytically inactive pseudokinase domain (JH2). JH2 is crucial for inhibition of basal Jak activity, but the mechanism of this regulation has remained elusive. We show that JH2 negatively regulated J...
Na minha lista:
| Udgivet i: | Mol Biol Cell |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Cell Biology
2003
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153113/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12686600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E02-06-0342 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|