Autoinhibition of Jak2 Tyrosine Kinase Is Dependent on Specific Regions in Its Pseudokinase Domain

Jak tyrosine kinases have a unique domain structure containing a kinase domain (JH1) adjacent to a catalytically inactive pseudokinase domain (JH2). JH2 is crucial for inhibition of basal Jak activity, but the mechanism of this regulation has remained elusive. We show that JH2 negatively regulated J...

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Veröffentlicht in:	Mol Biol Cell
Hauptverfasser:	Saharinen, Pipsa, Vihinen, Mauno, Silvennoinen, Olli
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Cell Biology 2003
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153113/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12686600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E02-06-0342
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