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Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors

Janus kinases (JAK) are the mediators of a variety of cytokine signals via their cognate receptors that result in activation of intracellular signaling pathways. Alterations in JAK1, JAK2, JAK3 and TYK2 signaling contribute to different disease states, and dysregulated JAK-STAT signaling is associat...

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Bibliografiske detaljer
Main Authors: Meyer, Sara C., Levine, Ross L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990645/
https://ncbi.nlm.nih.gov/pubmed/24583800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0279
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