Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

Mutations in epigenetic modifiers and signaling factors often co-occur in myeloid malignancies, including TET2 and NRAS mutations. Concurrent Tet2 loss and Nras(G12D) expression in hematopoietic cells induced myeloid transformation, with a fully penetrant, lethal chronic myelomonocytic leukemia (CMM...

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Publicado no:Cancer Cell
Main Authors: Kunimoto, Hiroyoshi, Meydan, Cem, Nazir, Abbas, Whitfield, Justin, Shank, Kaitlyn, Rapaport, Franck, Maher, Rebecca, Pronier, Elodie, Meyer, Sara C., Garrett-Bakelman, Francine E., Tallman, Martin, Melnick, Ari, Levine, Ross L., Shih, Alan H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760367/
https://ncbi.nlm.nih.gov/pubmed/29275866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.11.012
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