Chromatin structure predicts epigenetic therapy responsiveness in sarcoma

Por Mills, Joslyn, Hricik, Todd, Siddiqi, Sara, Matushansky, Igor
Publicado em 2011

MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21(st) century

Por Matushansky, Igor, Charytonowicz, Elizabeth, Mills, Joslyn, Siddiqi, Sara, Hricik, Todd, Cordon-Cardo, Carlos
Publicado em 2009

Characterization and comparison of the properties of sarcoma cell lines in vitro and in vivo

Por MILLS, Joslyn, MATOS, Tulio, CHARYTONOWICZ, Elizabeth, HRICIK, Todd, CASTILLO-MARTIN, Mireia, REMOTTI, Fabrizio, LEE, Francis Y, MATUSHANSKY, Igor
Publicado em 2009

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

Por Zhang, Su-Jiang, Rampal, Raajit, Manshouri, Taghi, Patel, Jay, Mensah, Nana, Kayserian, Andrew, Hricik, Todd, Heguy, Adriana, Hedvat, Cyrus, Gönen, Mithat, Kantarjian, Hagop, Levine, Ross L., Abdel-Wahab, Omar, Verstovsek, Srdan
Publicado em 2012

Transcriptomic and Phospho-Proteomic Analyses of Erythroblasts Expanded in vitro From Normal Donors and From Patients with Polycythemia Vera

Por Hricik, Todd, Federici, Giulia, Zeuner, Ann, Alimena, Giuliana, Tafuri, Agostino, Tirelli, Valentina, Varricchio, Lilian, Masiello, Francesca, Ciaffoni, Fiorella, Vaglio, Stefania, Petricoin, Emanuel F., Girelli, Gabriella, Levine, Ross L., Migliaccio, Anna Rita F.
Publicado em 2013

The Polycomb Group Protein L3MBTL1 Represses a SMAD5-Mediated Hematopoietic Transcriptional Program in Human Pluripotent Stem Cells

Por Perna, Fabiana, Vu, Ly P., Themeli, Maria, Kriks, Sonja, Hoya-Arias, Ruben, Khanin, Raya, Hricik, Todd, Mansilla-Soto, Jorge, Papapetrou, Eirini P., Levine, Ross L., Studer, Lorenz, Sadelain, Michel, Nimer, Stephen D.
Publicado no Stem Cell Reports (2015)

Engraftment of Human Primary Acute Myeloid Leukemia Defined by Integrated Genetic Profiling in NOD/SCID/IL2rγnull Mice for Preclinical Ceramide-Based Therapeutic Evaluation

Por Barth, Brian M, Keasey, Nichole R, Wang, Xujung, Shanmugavelandy, Sriram S, Rampal, Raajit, Hricik, Todd, Cabot, Myles C, Kester, Mark, Wang, Hong-Gang, Shultz, Leonard D, Tallman, Martin S, Levine, Ross L, Loughran, Thomas P, Claxton, David F
Publicado no J Leuk (Los Angel) (2014)

Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

Por Rampal, Raajit, Al-Shahrour, Fatima, Abdel-Wahab, Omar, Patel, Jay P., Brunel, Jean-Philippe, Mermel, Craig H., Bass, Adam J., Pretz, Jennifer, Ahn, Jihae, Hricik, Todd, Kilpivaara, Outi, Wadleigh, Martha, Busque, Lambert, Gilliland, D. Gary, Golub, Todd R., Ebert, Benjamin L., Levine, Ross L.
Publicado em 2014

Heterodimeric JAK-STAT Activation as a Mechanism of Persistence to JAK2 Inhibitor Therapy

Por Koppikar, Priya, Bhagwat, Neha, Kilpivaara, Outi, Manshouri, Taghi, Adli, Mazhar, Hricik, Todd, Liu, Fan, Saunders, Lindsay M., Mullally, Ann, Abdel-Wahab, Omar, Leung, Laura, Weinstein, Abby, Marubayashi, Sachie, Goel, Aviva, Gönen, Mithat, Estrov, Zeev, Ebert, Benjamin L., Chiosis, Gabriela, Nimer, Stephen D., Bernstein, Bradley E., Verstovsek, Srdan, Levine, Ross L.
Publicado em 2012

ASXL1 Mutations Promote Myeloid Transformation Through Loss of PRC2-Mediated Gene Repression

Por Abdel-Wahab, Omar, Adli, Mazhar, LaFave, Lindsay M., Gao, Jie, Hricik, Todd, Shih, Alan H., Pandey, Suveg, Patel, Jay, Chung, Young Rock, Koche, Richard, Perna, Fabiana, Zhao, Xinyang, Taylor, Jordan E., Park, Christopher Y., Carroll, Martin, Melnick, Ari, Nimer, Stephen D., Jaffe, Jacob D., Aifantis, Iannis, Bernstein, Bradley E., Levine, Ross L
Publicado em 2012

JAK-STAT Pathway Activation in Malignant and Non-Malignant Cells Contributes to MPN Pathogenesis and Therapeutic Response

Por Kleppe, Maria, Kwak, Minsuk, Koppikar, Priya, Riester, Markus, Keller, Matthew, Bastian, Lennart, Hricik, Todd, Bhagwat, Neha, McKenney, Anna Sophia, Papalexi, Efthymia, Abdel-Wahab, Omar, Rampal, Raajit, Marubayashi, Sachie, Chen, Jonathan J., Romanet, Vincent, Fridman, Jordan S., Bromberg, Jacqueline, Teruya-Feldstein, Julie, Murakami, Masato, Radimerski, Thomas, Michor, Franziska, Fan, Rong, Levine, Ross L.
Publicado no Cancer Discov (2015)

Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

Por Rampal, Raajit, Ahn, Jihae, Abdel-Wahab, Omar, Nahas, Michelle, Wang, Kai, Lipson, Doron, Otto, Geoff A., Yelensky, Roman, Hricik, Todd, McKenney, Anna Sophia, Chiosis, Gabriela, Chung, Young Rock, Pandey, Suveg, van den Brink, Marcel R. M., Armstrong, Scott A., Dogan, Ahmet, Intlekofer, Andrew, Manshouri, Taghi, Park, Christopher Y., Verstovsek, Srdan, Rapaport, Franck, Stephens, Philip J., Miller, Vincent A., Levine, Ross L.
Publicado no Proc Natl Acad Sci U S A (2014)

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

Por Shih, Alan H., Jiang, Yanwen, Meydan, Cem, Shank, Kaitlyn, Pandey, Suveg, Barreyro, Laura, Antony-Debre, Ileana, Viale, Agnes, Socci, Nicholas, Sun, Yongming, Robertson, Alexander, Cavatore, Magali, de Stanchina, Elisa, Hricik, Todd, Rapaport, Franck, Woods, Brittany, Wei, Chen, Hatlen, Megan, Baljevic, Muhamed, Nimer, Stephen D., Tallman, Martin, Paietta, Elisabeth, Cimmino, Luisa, Aifantis, Iannis, Steidl, Ulrich, Mason, Chris, Melnick, Ari, Levine, Ross L.
Publicado no Cancer Cell (2015)

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

Por Zhang, Li, Tran, Ngoc-Tung, Su, Hairui, Wang, Rui, Lu, Yuheng, Tang, Haiping, Aoyagi, Sayura, Guo, Ailan, Khodadadi-Jamayran, Alireza, Zhou, Dewang, Qian, Kun, Hricik, Todd, Côté, Jocelyn, Han, Xiaosi, Zhou, Wenping, Laha, Suparna, Abdel-Wahab, Omar, Levine, Ross L, Raffel, Glen, Liu, Yanyan, Chen, Dongquan, Li, Haitao, Townes, Tim, Wang, Hengbin, Deng, Haiteng, Zheng, Y George, Leslie, Christina, Luo, Minkui, Zhao, Xinyang
Publicado no eLife (2015)

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

Por Abdel-Wahab, Omar, Gao, Jie, Adli, Mazhar, Dey, Anwesha, Trimarchi, Thomas, Chung, Young Rock, Kuscu, Cem, Hricik, Todd, Ndiaye-Lobry, Delphine, LaFave, Lindsay M., Koche, Richard, Shih, Alan H., Guryanova, Olga A., Kim, Eunhee, Li, Sheng, Pandey, Suveg, Shin, Joseph Y., Telis, Leon, Liu, Jinfeng, Bhatt, Parva K., Monette, Sebastien, Zhao, Xinyang, Mason, Christopher E., Park, Christopher Y., Bernstein, Bradley E., Aifantis, Iannis, Levine, Ross L.
Publicado em 2013

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

Por Rampal, Raajit, Alkalin, Altuna, Madzo, Jozef, Vasanthakumar, Aparna, Pronier, Elodie, Patel, Jay, Li, Yushan, Ahn, Jihae, Abdel-Wahab, Omar, Shih, Alan, Lu, Chao, Ward, Patrick S., Tsai, Jennifer J., Hricik, Todd, Tosello, Valeria, Tallman, Jacob E., Zhao, Xinyang, Daniels, Danette, Dai, Qing, Ciminio, Luisa, Aifantis, Iannis, He, Chuan, Fuks, Francois, Tallman, Martin S., Ferrando, Adolfo, Nimer, Stephen, Paietta, Elisabeth, Thompson, Craig B., Licht, Jonathan D., Mason, Chris, Godley, Lucy A., Melnick, Ari, Figueroa, Maria E., Levine, Ross L.
Publicado no Cell Rep (2014)

Loss of BAP1 function leads to EZH2-dependent transformation

Por LaFave, Lindsay M., Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D., Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K., Campbell, John E., Blum, Gil, Shi, Xinxu, Doud, Emma H., Krivtsov, Andrei V., Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S., Thomas, Paul M., Kelleher, Neil L., Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A., Levine, Ross L.
Publicado no Nat Med (2015)

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Por Li, Sheng, Garrett-Bakelman, Francine E., Chung, Stephen S., Sanders, Mathijs A., Hricik, Todd, Rapaport, Franck, Patel, Jay, Dillon, Richard, Vijay, Priyanka, Brown, Anna L., Perl, Alexander E., Cannon, Joy, Bullinger, Lars, Luger, Selina, Becker, Michael, Lewis, Ian D., To, Luen Bik, Delwel, Ruud, Löwenberg, Bob, Döhner, Hartmut, Döhner, Konstanze, Guzman, Monica L., Hassane, Duane C., Roboz, Gail J., Grimwade, David, Valk, Peter J.M., D’Andrea, Richard J., Carroll, Martin, Park, Christopher Y., Neuberg, Donna, Levine, Ross, Melnick, Ari M., Mason, Christopher E.
Publicado no Nat Med (2016)