Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

RBM15, an RNA binding protein, determines cell-fate specification of many tissues including blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4). Overexpression of PRMT1 i...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zhang, Li, Tran, Ngoc-Tung, Su, Hairui, Wang, Rui, Lu, Yuheng, Tang, Haiping, Aoyagi, Sayura, Guo, Ailan, Khodadadi-Jamayran, Alireza, Zhou, Dewang, Qian, Kun, Hricik, Todd, Côté, Jocelyn, Han, Xiaosi, Zhou, Wenping, Laha, Suparna, Abdel-Wahab, Omar, Levine, Ross L, Raffel, Glen, Liu, Yanyan, Chen, Dongquan, Li, Haitao, Townes, Tim, Wang, Hengbin, Deng, Haiteng, Zheng, Y George, Leslie, Christina, Luo, Minkui, Zhao, Xinyang
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775220/
https://ncbi.nlm.nih.gov/pubmed/26575292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07938
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