Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Genetic heterogeneity contributes to clinical outcome and progression of most tumors. Yet, little is known regarding allelic diversity for epigenetic compartments and almost no data exists for acute myeloid leukemia (AML). Here we examined epigenetic heterogeneity as assessed by cytosine methylation...

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Publicado no:Nat Med
Main Authors: Li, Sheng, Garrett-Bakelman, Francine E., Chung, Stephen S., Sanders, Mathijs A., Hricik, Todd, Rapaport, Franck, Patel, Jay, Dillon, Richard, Vijay, Priyanka, Brown, Anna L., Perl, Alexander E., Cannon, Joy, Bullinger, Lars, Luger, Selina, Becker, Michael, Lewis, Ian D., To, Luen Bik, Delwel, Ruud, Löwenberg, Bob, Döhner, Hartmut, Döhner, Konstanze, Guzman, Monica L., Hassane, Duane C., Roboz, Gail J., Grimwade, David, Valk, Peter J.M., D’Andrea, Richard J., Carroll, Martin, Park, Christopher Y., Neuberg, Donna, Levine, Ross, Melnick, Ari M., Mason, Christopher E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938719/
https://ncbi.nlm.nih.gov/pubmed/27322744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4125
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